Biopharmaceutical Process Development

The efficient expression of a therapeutic protein in microbial or mammalian cells is often a bottleneck in the production of biopharmaceuticals.

The efficient expression of a therapeutic protein in microbial or mammalian cells is often a bottleneck in the production of biopharmaceuticals.

At Fujifilm Diosynth Biotechnologies we combine our novel technologies, such as pAVEway™, with our extensive R&D know-how to design and assemble a process that is robust, scaleable and suitable for cGMP production of your product.

Our technologies include:

• Broad expression system development experience - microbial, yeast, mammalian, insect
• Proprietary pAVEway™ microbial expression and gene manipulation system facilitating rapid development of industry leading productivities
• Extensive phase-appropriate development experience - preclinical through to commercial processes
• Broad protein purification experience - gained from development of >150 different protein production processes
• Innovative technologies for application to client projects including novel secretion leaders, antibiotic free selection, antibody fragment toolkit, mAb platform purification process
• In-house process statistical support for development giving enhanced approaches to experimental robustness
• Application of high throughput approaches in development - upstream, downstream, analytical 
• Broad experience with the development of chemical modification methods for proteins including PEGylation and conjugation.