Interested In Improving Cell Culture Cell Clarification Efficiency?
The first step in the production of therapeutics and diagnostics by cell culture processes involves separating cell mass from the product. Separation of the cell culture fluid challenges the process engineer to select a separation method that results in maximum product yield, complies with FDA regulatory requirements, and offers acceptable economic performance.
See how depth filtration can be used to address the issues associated with tangential flow filtration and centrifugation.
By Brad Larson and Peter Banks, Applications Department, BioTek Instruments, Inc.
Current biochemical assay technologies examine enzyme activity and G9a and BET bromodomain protein inhibition. Cell-based assays for these epigenetic players were previously limited to the detection of specific histone modifications using antibodies, with antibody specificity being an issue.
By Leon VanWormer, MBA, Sartorius Stedim Biotech
Although traditional stainless steel equipment has lost a great deal of market penetration to single-use alternatives over the past decade, there still is a need for quality filter cartridge systems for sterilizing and polishing filtration processes.
By Christine Park, Quality Architech
Document control is always an interesting topic for discussion. It seems like a simple topic and area for compliance, but I often run into companies with document control systems that are overly complicated and difficult to manage.
By Jean Bédard, President and CEO, Infitrak
The FDA, Health Canada, and other regulators are increasingly putting the pressure on drug manufacturers to be in compliance with GMP requirements for controlled temperature storage.
By Brian Kohr, President and CEO, Csafe
Global sourcing is a 'business-essential' that continues to be of increasing importance to life sciences companies. As manufacturers adapt to changing market conditions, consolidate their operations, and focus thought leadership to work as one company across borders, continents, and markets, the drive to make cost and efficiency savings becomes ever more demanding.