2.15.12 -- Trends To Understand Molecular Structure, Properties, And Pathways

The commercial drug pipeline has made a dramatic shift, from conventional small-molecule drugs to biologic-based pharmaceuticals, all in the past five years. This new class of protein-based pharmaceuticals is believed to be inherently safer than small molecule drugs, and will enable longer innovator exclusivity, because today it is not possible to create an identical copy of the drug, taking biogenerics out of the picture.
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Capture Of An Acid-Sensitive Recombinant Protein From E. coli Lysate Using Mixed-Mode Chromatography
Dr. Magali Toueille, Dr. Jérôme Champagne, Dr. René Gantier, Dr. Sylvio Bengio, and Dr. John Woodgate, Pall Life Sciences – Biopharmaceuticals

Mixed-mode chromatography in an e-coli protein demonstrates good capacity and 300 fold scale-up. HyperCel™ MEP, HEA, and PPA mixed-mode chromatography sorbents offer unique selectivity, are an efficient alternative to hydrophobic interaction sorbents, and can be used for intermediate step purification of monoclonal antibodies and for many other applications in the biopharmaceutical industry. Read more.

Fast GC-MS/MS For High-Throughput Pesticide Analysis
By Igor Fochi, Elena Ciceri, and Hans-Joachim Huebschmann, Thermo Scientific

A wide variety of phytosanitary products are commonly applied in agricultural crops in order to increase production yield and obtain high-quality products. Consequently, the control of pesticide residue levels by the performance of monitoring programs is currently an increasing concern for producers, traders, and consumers. Read more.

35Å Media For High-Loading Adsorption
By Oliver Genz, Thomas Pauly, and Dr. Ian Chappell, Grace

35Å media reduces related solvent disposal costs, which can lead to an overall cost savings in process-scale chromatography costs, due to the fact that solvent costs are actually much higher than media costs in the production process. Read more.

Thank you for reading Bioresearch Online's Chromatography Impact. Do you have a topic you would like to see addressed in future issues, or do you have experience with chromatography that you could share? Let us know!