SoloHill Microcarriers In A 25L PadReactor Single-Use Bioreactor

Microcarriers provide a large surface area for growth of anchorage-dependent cell types and make possible the use of bioreactors for generation of large numbers of adherent cells under current good manufacturing processes (cGMP). Presently, microcarriers are used in a wide array of applications with a diverse range of cell types for the production of biologicals and vaccines, and for the generation of stem cells for cell therapies and regenerative medicine. Within each application there exists the challenge of providing cells with optimal environmental conditions for cell growth and for the synthesis of products of superior quality. To meet this challenge, SoloHill Engineering offers an assortment of microcarrier types with varying densities and unique combinations of surface chemistries and coatings. This portfolio provides users with options for choosing a microcarrier which promotes optimal growth and performance of their particular cell line in their chosen bioreactor under serum-containing or animal-protein-free(APF) conditions.

The recent emergence of disposable bioreactor technology, such as the PadReactor TM system, has provided a useful platform for the manufacture of biologics.

These systems expedite cGMP clinical and commercial production by improving process reliability and reducing costs with greater flexibility. The bioreactor vessel, which offers comparable functionality to classical stirred tank bioreactors, is a single use cube-shaped bag integrating an internal paddle mixing with sparger system. The PadReactor system offers an open architecture controller platform which gives the end user the opportunity to use the companion control system offered by ATMI or to choose a preferred controller.