Large Scale Cultivation Of CHO Cells In The Stirred Single-Use Bioreactor BIOSTAT® CultiBag STR

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•Application Note: Large Scale Cultivation Of CHO Cells In The Stirred Single-Use Bioreactor BIOSTAT® CultiBag STR

By Sartorius Stedim Biotech

The Sartorius Stedim Biotech BIOSTAT® CultiBag STR is the first and only single-use bioreactor which was engineered based on the well-established principles known from classical reusable bioreactors.

Single-use bioreactors are nowadays widely accepted in research and manufacturing applications of mainly mammalian and insect cell cultures. They have several advantages compared to traditional stainless steel assemblies. Conventional production plants are commonly dedicated to a specific product. In contrast, singleuse bioreactors are tremendously flexible because all piping is realized in the disposable bag, which can be designed according to the application. Costs are reduced by eliminating the space consuming and expensive CIP and SIP installations and reducing the needed production turnaround times. In combination with the reduced efforts for validation, this eventually results in a shorter time to market and a faster return on investment. On the other hand, stainless steel bioreactors rely on proven engineering principles. For decades, stirred tank bioreactors featuring a cylindrical vessel, stirred by impellers mounted on a rigid shaft and gassed via a submerged sparger, have been the gold standard. They are well characterized in terms of performance, scalability, optimization steps and design.

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•Application Note: Large Scale Cultivation Of CHO Cells In The Stirred Single-Use Bioreactor BIOSTAT® CultiBag STR