Innovative Features Of Bio-Rad® InPlace™ Chromatography Columns Simplify Packing Procedures For Any Media Type

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•Tech Note: Innovative Features Of Bio-Rad® InPlace™ Chromatography Columns Simplify Packing Procedures For Any Media Type

By Bio-Rad Laboratories, Inc.

The Bio-Rad InPlace process chromatography columns are designed for flexibility to suit packing needs at pilot and manufacturing scale. Every type of media from soft, highly compressible resin to rapidly settling, rigid, noncompressible beads benefit from the unique InPlace column design.

The packing procedures for the Bio-Rad InPlace column are similar to those for open column systems that are often used at laboratory scale and pilot scale. The packing protocols are directly scalable because the media bed is consolidated uniformly using axial compression packing, flow packing, or a combination of both. With alternative pack-in-place chromatography columns using a central nozzle, the bed often forms unevenly, with a dense region at the walls of the column and a less compact area near the center of the bed. In some cases the reverse is observed, with a very tightly packed bolus of material forming very close to the nozzle as the packing pump reaches its stall point.

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•Tech Note: Innovative Features Of Bio-Rad® InPlace™ Chromatography Columns Simplify Packing Procedures For Any Media Type