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•Case Study: Viral Clearance Using Ion-Exchange Membrane Adsorber Capsules

By Pall Life Sciences - BioPharmaceuticals

Viral contamination of cell banks is a potential risk in recombinant proteins produced by cell lines from animal or human origin. Licensed products must therefore be subjected to a processspecific virus clearance strategy based on:

• Testing of the cell line and raw material for viral contaminants.
• Determining the viral clearance capability of the downstream process.
• Testing for contaminating viruses at relevant process stages.
• Protection of chromatography columns
• Capsule format for single or multi-use operations
• Scalability

The feed liquid was spiked with a non-enveloped minute mouse virus MMV, Reo3, and a retrovirus xenotrophic murine leukaemia virus xMuLV.

Click Here To Download:
•Case Study: Viral Clearance Using Ion-Exchange Membrane Adsorber Capsules