Bio-Rad's New UNOsphere Rapid S Cation Exchange Media Delivers Speed And Throughput In Large-Scale Protein Purification

Hercules, CA – Bio-Rad Laboratories, Inc., a multinational manufacturer and distributor of life science research and clinical diagnostic products, announced the launch of the UNOsphere™ Rapid S media, a strong cation exchange support for protein purification. The support has been optimized to deliver speed and throughput in capture and intermediate purification steps. UNOsphere Rapid S support combines high binding capacity, fast mass transfer, excellent flow characteristics, and robust physical properties to make it an exceptional choice for process chromatography.

UNOsphere media are based on a unique polymerization process, which yields macroporous, hydrophilic beads that are ideal for biomolecule separations. Incorporation of the sulfonic acid ligand directly into the matrix during the polymerization process ensures consistent batch-to-batch reproducibility. The performance of UNOsphere Rapid S support is not compromised by exposure to NaOH in commonly used sanitization and clean-in-place protocols.

UNOsphere Rapid S support is intended for use in large-scale purification processes. The macroporous structure of the UNOsphere matrix affords the use of high flow rates while maintaining very low backpressures. With typical buffers and running conditions, it is possible to achieve linear velocities in excess of 1,000 cm/hr in full-scale columns with backpressures below 2 bar. The use of high flow processes increases productivity, decreases cycle times, and reduces the degradation of proteins due to exposure to proteases.

UNOsphere Rapid S support is designed for optimal performance and is produced in a validated manufacturing process to ensure batch-to-batch and run-to-run consistency. A dedicated applications and technical support team is available to answer questions and assist with process separation designs.

About Bio-Rad
Bio-Rad Laboratories, Inc. (AMEX: BIO and BIOb) has remained at the center of scientific discovery for more than 50 years, manufacturing and distributing a broad range of products for the life science research and clinical diagnostic markets. The company is renowned worldwide among hospitals, universities, major research institutions, as well as biotechnology and pharmaceutical companies for its commitment to quality and customer service. Founded in 1952, Bio-Rad is headquartered in Hercules, California, and serves more than 85,000 research and industry customers worldwide through its global network of operations. The company employs approximately 6,300 people globally and had revenues approaching $1.5 billion in 2007.

SOURCE: Bio-Rad Laboratories, Inc.