Application Note
Application Note: Stem Cell Solutions With DASGIP Parallel Bioreactor Systems
Stem cell technology is now on the verge of achieving product status in regenerative medicine. The accompanying governmental regulations and demands for clinical studies demand validated approaches and as such reproducible experimental results. Therefore cultivation procedures need to be closely observed and precisely controlled – in researcher's smaller volumes as well as in larger production scales.
To satisfy stem cell's unique expansion and differentiation conditions of e.g. embryonic (ES), adult and induced pluripotent stem (iPS) cells, DASGIP has refined its cell cultivation products for dynamic cultivation. Individual solutions meet the specific demands for the cultivation of various stem cells, such as embryoid bodies, neurospheres or adherent cells (on microcarriers) in suspension.
Many different cultivation parameters influence the growth and behavior of stem cells. Conventionally, particular attention is paid on the media composition. The influence of cytokines and growth factors on the cell expansion and proliferation has been extensively studied. The upcoming production stage, though, adds on new, important physical parameters whose influence on the cell behavior is less investigated.
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