Article
Scale-Up To 1000 L Perfusion Cell Culture In A Disposable Stirred-Tank Bioreactor
March 17, 2008
•Application Brief: Scale-Up To 1000 L Perfusion Cell Culture In A Disposable Stirred-Tank Bioreactor
Bioprocess scientists have long sought to expand the application of perfusion cell culture in order to achieve the theoretical productivity gains it promises compared to batch and fed-batch approaches. However, practical challenges often thwart those efforts.
Working in close cooperation with a leading biopharmaceutical client, Xcellerex has developed, scaled-up and operated a perfusion mode operation at the 200L (160L working volume) and 1000L scale using exclusively single-use process equipment. The 1000L process was operated for one month, with 12 harvests over 19 days. The program concluded with a successful demonstration of process viability and reliability that exceeded the client's expectations.
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•Application Brief: Scale-Up To 1000 L Perfusion Cell Culture In A Disposable Stirred-Tank Bioreactor
SOURCE: Xcellerex
