Application Note
Quality Control Of Small Molecule Pharmaceuticals Using Spectrophotometry
Click Here To Download:
•Application Note: Quality Control Of Small Molecule Pharmaceuticals Using Spectrophotometry
By Thermo Scientific NanoDrop Products
The control of pharmaceutical product quality is essential to ensure safe and effective use in patients. The Thermo Scientific NanoDrop 2000 Spectrophotometer offers a rapid and cost-effective method for spot-checking batch quality at various points in the pharmaceutical production line. The concentrations of many compounds can be determined based upon UV-Visible absorbance, and, in some instances, purity can also be monitored by analyzing spectral data.
In this study, UV absorbance spectra measured using a NanoDrop™ 2000 Spectrophotometer were used to compare several acetaminophen samples from various sources with a known standard. In addition, reproducibility was assessed within each sample to determine the affects of aggregates or light scattering in the unknown samples.
The auto-ranging pathlength capabilities of the NanoDrop 2000 allow this instrument to quantify pharmaceutical samples across a much broader concentration range than is possible using a conventional cuvette-based spectrophotometer. By automatically selecting the optimum pathlength (ranging from 1.0 mm to 0.05 mm) the NanoDrop 2000 can accurately measure the absorbance of a sample across a dynamic range nearly 300 fold greater than that of a cuvette- based system.
Click Here To Download:•Application Note: Quality Control Of Small Molecule Pharmaceuticals Using Spectrophotometry
