Article
Production Of Pharmaceutical Compounds Through Microbial Fermentation
June 24, 2011
•Article: Production Of Pharmaceutical Compounds Through Microbial Fermentation
By SAFC
The original definition of fermentation is ‘the anaerobic conversion of sugar to carbon dioxide and alcohol by yeast', and most of us will have had first-hand experience of the fermentation process through its most famous and popular use - the brewing of beer.
This original definition has been expanded over time to ‘the conversion of organic materials into relatively simple substances by microorganisms- essentially efficient, flexible bio factories.' During their growth and lifespan microorganisms build a wide range of different molecules types required for viability and multiplication; adaptation to changing environment; stressful conditions and defence against hostile, competitive microbial threats.
Microorganisms that are typically used within the pharmaceutical industry include: prokaryotes such as Bacteria (e.g. Escherichia coli, Staphylococcus aureus) and Streptomycetes (e.g. Streptomyces spp, Actinomyces spp), eukaryotes such as Filamentous Fungi (e.g., Nigrospora spp, Aspergillus spp,) and Yeast (e.g. Saccharomyces cereviciae, Pichia pastoris).
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