Product/Service
Integrity™ iCELLis™ Single-Use Bioreactor For Process Intensification
•Brochure: Integrity iCELLis Single-Use Bioreactor For Process Intensification
•Scalable Production Of Recombinant AAV Vectors From A549-Based Packaging Cell Lines In The iCELLis™ System
•Viral Vaccine Production With VERO Cells In The iCELLis™ Nano Disposable Fixed-Bed Bioreactor
The iCELLis™ system, the world's first fully-integrated, high-cell density bioreactor, is designed to simplify your process by combining the advantages of single-use technologies with the benefits of a fixed-bed system. The compact system—designed for quick imple¬mentation and ease-of-use—represents a new generation of single-use bioreactors.
Central to the iCELLis bioreactor technology is the use of a compact fixed-bed with pre-packed custom macrocarriers. This matrix contains medical-grade polyester microfibers and provides a large growth surface area in a compact bioreactor volume. Compared to a standard stirred-tank bioreactor using microcarriers, the iCELLis system avoids several delicate and time-consuming procedures, including manual operations, sterilization and hydration of microcarriers and bead-to-bead transfers from preculture to final process.
With the biomass multiplication occurring in the fixed-bed, iCELLis bioreactors can be inoculated at very low density. The number and volumes of pre-culture steps are reduced considerably; two CF40 (2.5 m2) or six Roller Bottles (1750 cm2) are sufficient to inoculate an iCELLis 1000 bioreactor. As a result of this process simplification, manual operations and associated costs are reduced dramatically.
Evenly-distributed media circulation is achieved by a built-in magnetic drive impeller, ensuring low shear stress and high cell viability. The cell culture medium flows through the fixed-bed from the bottom to the top. At the top, the medium falls as a thin film down the outer wall where it takes up O2to maintain high KLa the in the bioreactor. This unique waterfall oxygenation, together with a gentle agitation and biomass immobilization, enables the compact iCELLis system to achieve and maintain high cell densities, equaling the pro¬ductivity of much larger stirred-tank units.
Process simplification, from vial thawing to final product, is at the heart of the iCELLis platform. As cells are immobilized in the fixed-bed and the iCELLis system operates in perfusion mode, there is no need for centrifugation to harvest the cells, which further simplifies the downstream process.
Click Here To Download:•Brochure: Integrity iCELLis Single-Use Bioreactor For Process Intensification
•Scalable Production Of Recombinant AAV Vectors From A549-Based Packaging Cell Lines In The iCELLis™ System
•Viral Vaccine Production With VERO Cells In The iCELLis™ Nano Disposable Fixed-Bed Bioreactor
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