Guest Column
Article: How To Choose An Industrial Cation Exchanger For IgG Purification
By Pete Gagnon
Cation-exchange chromatography is the third most used industrial method for antibody purification after anion-exchange and protein A affinity chromatography. It is most commonly used as an intermediate step but continues to attract attention as a capture method. Whichever application may be intended, end users seek a common set of performance characteristics. They include high capacity and recovery, high purification factor, a high degree of process control, high lot-to-lot reproducibility, and easy cleanability and sanitizability.
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