Presentation
Presentation: Comparison Of Results From Theoretical Sequence Search Engines And Peptide Mass Spectral Libraries For Selected Biological Samples
Source: Pittcon 2012
Summary
- Spectral library searching has many theoretical advantages over sequence searching
- Decoy libraries created from other species used with a simple target/decoy bias correction enable direct comparisons at FDR .01 with standard methods.
- Even at "low" coverage, library searching yielded equivalent or better results for real world samples.
- Library searching is an excellent addition to standard multiple search engine strategy.
- For known standards with high coverage, library searching is far more sensitive.
Register Today. It's Fast And Free.
The content you requested is only available to registered users of Bioresearch Online. By registering now, you'll get exclusive access to this piece of content and thousands of addtional articles and product reviews across our entire network of sites.
Already Registered? Sign In.
