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•Article: Advances In Separation And Purification: Purifying Monoclonal Antibodies

Pete Cagnon, Frank Hensel, Richard Richeri

The affinity capture paradigm that dominates industrial IgG purification has proven unsuitable for IgMs because, in most cases, they are affected adversely by harsh elution conditions. The large size of IgMs also a challenge because it limits the operating conditions and performance of traditional porous-particle-based chromatography media. This article describes how these challenges can be overcome with available technology to develop effective manufacturing procedures for IgM monoclonal antibodies.

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•Article: Advances In Separation And Purification: Purifying Monoclonal Antibodies

SOURCE: Bio-Rad Laboratories, Inc.