Article
A Universal Single-Use Mixer - Concept Or Reality?
June 1, 2011
•Article: A Universal Single-Use Mixer – Concept Or Reality?
By Pall Life Sciences - BioPharmaceuticals
In recent years, various types of single-use mixers incorporating components such as paddles, stir-bars, recirculation loops, impellers and flat-bed rockers have been introduced. Sinclair and Monge reported that each type of mixer currently available wasrestricted by its design to specific applications, and that no systemwas optimal for general purpose mixing due to the wide range of applications and different mixing duties in bioprocessing including:
- Liquid/liquid mixing
- Solid/liquid mixing
- Suspensions
- Immiscible liquids
- Fluid viscosity
- Shear sensitive fluids
- Susceptibility to foaming
- Container shape/dimensions
- Process scale
- Mixing time
- Fluid contact materials
- Capital and running costs
- Sampling and monitoring
- Durability
- Power transfer
- Footprint
- Hardware requirements
- Temperature control
- Extended operation
- Particulate generation
With these considerations in mind, a project was set in place to develop a versatile single-use mixer suitable for a wide range of applications and supported by extensive performance testing to confirm its broad capabilities. A more detailed account of this project is being published elsewhere.
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