FEATURED ARTICLES

  • Patient Demand, Vaccines, And Drug Delivery: Q&A With Steve Wick Of 3M Drug Delivery Systems
    Patient Demand, Vaccines, And Drug Delivery: Q&A With Steve Wick Of 3M Drug Delivery Systems

    New technologies are changing the drug delivery approaches used for both small and large molecule manufacturers. Additionally, the more empowered patient is causing many pharma companies to re-evaluate their drug delivery strategies. We spoke with Steve Wick, Senior Technical Director for 3M Drug Delivery Systems, about these topics as well as how the drug delivery landscape might change over the next 5 to 10 years.  

    What technologies are currently changing drug delivery approaches for small molecules? For large molecules? How will these advances impact the pharmaceutical industry?

    For small molecules specifically, I believe that we will see two different trends in drug delivery. The first will be toward the targeting of drug delivery through the use of technology such as nanoparticles or even aptamers. 

  • Shipping With Active Packaging Containers: Three Pre-Flight Decisions That Impact The Success of High-Value Global Shipments
    Shipping With Active Packaging Containers: Three Pre-Flight Decisions That Impact The Success of High-Value Global Shipments

    It is the dead of winter in the northern hemisphere and the height of summer in the southern, with external temperature fluctuations exceeding 50 degrees. Flight delays have added precious days to the transport of your multi-million dollar shipment of blockbuster drug from South East Asia destined for Russia. In France, the roads are closed for days due to a monster snowstorm, with your irreplaceable shipment of investigational drugs stopped somewhere en route between Paris and the clinical trial site. Will all be lost, or can informed choices made before the shipment departs ensure product safety despite unforeseen circumstances?

  • Influence Of Silanol Content, Humidity And Temperature On Efficacy Of A Silica Based Carrier
    Influence Of Silanol Content, Humidity And Temperature On Efficacy Of A Silica Based Carrier

    Recently, silica based carriers have been widely used for the adsorption of oily and lipid based formulations. Using silica as adsorbent, liquid self emulsifying drug delivery systems could be formulated in tablet or capsule oral dosage form. For this application, an ideal carrier is one which possesses high adsorption capacity and immediate desorption or release at desired site. Three different types of carriers like Granulated fumed silica (GFS) Syloid® XDP-Mesoporous silica gel (MSG) and Magnesium aluminum silicate (MAS) were selected for this study. By Yogesh Choudhari, Upendra Reddy, and Fred Monsuur, Grace

  • Using Spray Drying For Flu Vaccines: What Challenges Do We Need To Overcome?
    Using Spray Drying For Flu Vaccines: What Challenges Do We Need To Overcome?

    When discussing the challenges of manufacturing flu vaccines, the conversation often shifts toward how manufacturers can meet the global demand each year. Currently there are some very innovative technologies aimed at addressing the challenge of manufacturing a larger supply of flu vaccines in a shorter amount of time, such as Novartis’ use of cell culture and Medicago and Fraunhofer’s use of tobacco plants. However, being able to deliver enough of a vaccine is only half the battle. It also needs to be delivered to its final destination within the appropriate temperature range. “It’s a huge misnomer for people who believe these technologies will unconstraint flu,” says Jim Robinson, VP of global technical operations, biological, and sterile products at Merck, who was involved in the manufacturing of billions of doses of flu vaccine prior to joining Merck. “The product still needs to get into a usable form and be delivered safely to the patient.”

  • BDP Week Highlights The Importance Of Communication In BioPharma
    BDP Week Highlights The Importance Of Communication In BioPharma

    At this year’s Biopharmaceutical Development and Production (BDP) Week, March 24-27 at the Hilton Bayfront Hotel, I attended several sessions that focused on how to strengthen the relationship between partners in the pharmaceutical industry. One overwhelming theme in each presentation was the importance of communicating effectively and clearly with everyone involved in a project.

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BIORESEARCH INSIGHT

  • Hygienic Processing: Elimination Of Dead Space Volume

    Hygienic processing places high demands on the reliability and cleanability of production facilities. These requirements are especially high in separation processes like filtration and chromatography and are significant in ensuring purity of media by maintaining sterile process conditions.

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FEATURED PRODUCTS

  • ISPE Baseline® Pharmaceutical Engineering Guides
    ISPE Baseline® Pharmaceutical Engineering Guides Created in partnership with the US Food and Drug Administration (FDA), the ISPE Baseline® Pharmaceutical Engineering Guide Series offers practical solutions to the complex, dynamic challenges facing facility designers today. In addition to providing an understanding of products and processes, the Guides also offer an outline of architectural and utility systems needed to meet government requirements...
  • Sterilizing Grade Filters
    Sterilizing Grade Filters Sterilizing Grade Filters of different membrane materials and pore size combinations for sterilizing grade filtration to remove viable microorganisms from the liquid or gas stream.
  • Safe Handling Of Cytotoxic Compounds
    Safe Handling Of Cytotoxic Compounds

    A limited number of companies have the capabilities of handling cytotoxic compounds safely and efficiently and even fewer offer expertise in R&D. BTL is unique in now being able to bring together its R&D expertise in the lyophilization of products, with a dedicated facility for cytotoxic products.

  • IOL Series Filter Housings
    IOL Series Filter Housings Pall IOL and IDL Single-round Housings are constructed of stainless steel and are designed for industrial applications (such as filtration of fluids in utilities areas).
  • Fluid Control Systems For Sterilizers And Washers
    Fluid Control Systems For Sterilizers And Washers

    Infection protection is a rapidly growing industry where sterility and reliability are crucial.

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BIORESEARCH ONLINE VIDEOS

  • Temperature Monitoring Technology for Healthcare Shipments
    Temperature Monitoring Technology for Healthcare Shipments

    Logistics expert Kevin O’Donnell, Senior Partner, Exelsius Cold Chain Management, presents the basics of temperature monitoring for healthcare shipments. From simple temperature indicators to more sophisticated electronic systems that include intervention protocols, you have more options than you may think. Kevin Etter, Product Manager, UPS Global Healthcare Logistics Strategy Group, explains why it’s so important to know what's going on during high value shipments.

  • How To Assess Total Logistics Cost
    How To Assess Total Logistics Cost

    Watch this new video to learn new ways to calculate total logistics costs. Susan Li of the Healthcare Strategy Group at UPS reveals the true costs of packaging and shipping.

  • Biobanking And The Future Of Translational Medicine: Dr Gyorgy Marko-Varga Interview 2 Of 3 Dr Gyorgy Marko-Varga highlights how biobanking will be critical to realize the promise of Translational Medicine and what challenges we need to overcome quality hurdles going forward.
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FEATURED SUPPLIERS

  • Envirotainer
    Envirotainer

    We are a global market leading provider of an air cargo cold chain transportation concept to pharmaceutical companies and their logistics partners. We are unique and the benchmark for global air cargo cold chain management and logistics solutions.

  • ISPE
    ISPE

    ISPE, the International Society for Pharmaceutical Engineering, is the world’s largest not-for-profit association serving its Members through leading scientific, technical and regulatory advancement throughout the pharmaceutical lifecycle.

  • DASGIP Information and Process Technology GmbH an Eppendorf company
    DASGIP Information and Process Technology GmbH an Eppendorf company

    Rapid technological advances in biotech and pharmaceutical industries have created increasing demands in research and development. DASGIP Parallel Bioreactor Systems for the cultivation of bacterial, phototrophic, animal and human cells at bench top scale support scientists and engineers to accomplish their projects quicker and more efficiently.

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CMO CRO LEADERSHIP AWARDS

Life Science Leader developed the CMO and CRO Leadership Awards based on industry leading research conducted by Nice Insight. The awards help pharma and biopharm companies focus on potential partners who can handle their projects and are considered reputable in the industry. Click on the logos above to visit this year’s winners.

 

ABOUT BIORESEARCH ONLINE

Welcome to BioResearch Online, the premier Internet source of useful and timely information for the worldwide bioresearch and life sciences industries. This site is designed to serve the needs of laboratory directors, laboratory managers, researchers, scientists, university faculty members, business executives, and other industry professionals. BioResearch Online provides daily news updates and in-depth feature stories about drug discovery, research and development advancements, university-industry collaborations, and regulatory issues.

On this site, industry professionals will find information about new products and technology, bioanalytics, bioreactors, biopurification, bioproduction products, bioprocess sensors, cell culture media, biopharm contract manufacturing, chromatography, lab informatics, lab automation, laboratory systems and equipment, molecular and cell biology, pipettors, assay instruments, genetic sequencing, immunochemicals, enzymes, hardware and software systems, and more.

Bioresearch Online is part of the Life Science Connect media group. The vision of Life Science Leader and Life Science Connect is to help facilitate connections and foster collaborations in pharmaceutical and medical device development to find ways to get more life-saving and life-improving therapies to market in an efficient manner. Connect, Collaborate, Contribute.

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 UPCOMING TRAINING COURSES

Building Accountability on Your Clinical Teams

April 29, 2014
1pm-2:30pm EDT, Online Training

Root Cause Analysis for Clinical Research Professionals

May 5, 2014
1pm-3pm EDT, Online Training
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WEBINARS

  • H.R. 3204 Drug Quality And Security Act
    H.R. 3204 Drug Quality And Security Act

    After so many years of struggling with how to comply with the California ePedigree requirement, we now need to know how to comply with the new federal requirement, H.R. 3204. This webinar will review DQSA requirements and timelines.

     

  • PAT-Enabled Process Optimization & Control

    PAT is a risk-based strategy for designing, analyzing and controlling manufacturing processes. The Critical Process Parameters (CPPs) are identified in line with the definition of the Critical Quality Attributes (CQAs) of intermediates or final products. PAT offers a number of tools for measuring and controlling these CPPs.
    Sartorius has the right choice of solutions you need: discover our world of Synchronized PAT Solutions.

  • Adoption of Membrane Chromatography in the Vaccine Industry
    Adoption of Membrane Chromatography in the Vaccine Industry

    This educational webinar will discuss a high throughput process development (HTPD) approach using Mustang® membrane to define the optimal operating conditions resulting in the best quality of the virus product and demonstrate the predictive power of this methodology as applied to the purification of influenza virus.

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BIO EVENTS

Stem Cell Summit 2014

April 24 - 25, 2014
Boston, MA

Building Accountability on Your Clinical Teams

April 29, 2014
1pm-2:30pm EDT, Online Training
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NORTHERN CALIFORNIA’S LIFE SCIENCE ASSOCIATION

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