| UNOsphere SUPrA Instruction Manual |
UNOsphere SUPrA™ media are affinity chromatography support based on recombinant protein A. The media are designed for process-scale purification of monoclonal antibodies. The protein A ligand is produced in E. coli without the use of material from animal origin. The UNOsphere base bead is a macroporous polymeric bead that is designed for robust and scaleable process applications.
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07/02/2009 |
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| Bulletin: Monoclonal Antibody Purification Using UNOsphere SUPrA Media |
The first step in purification of an important class of
therapeutic proteins, the polyclonal or monoclonal antibodies
(mAbs), is their capture from plasma or tissue culture
supernatants. Protein A–based media are by far the most
common class of affinity products used for this purpose. They
bind with high affinity to the Fc region of most subclasses of
antibodies and are one of the standard tools used in antibody
capture and purification. |
07/02/2009 |
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| Bulletin: UNOsphere SUPrA Affinity Chromatography Media |
UNOsphere SUPrA affinity media are designed
for process-scale purification of monoclonal
and polyclonal antibodies. These affinity media
are built on the proven UNOsphere matrix for
predictable performance over a wide range of
antibody concentrations. |
07/02/2009 |
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| Bulletin: CFT™ Ceramic Fluoroapatite Media |
CFT ceramic fluoroapatite, Ca10(PO4)6F2, is a rigid, spherical macroporous support used in the purification of biologically active compounds. CFT is a composite of fluoroapatite and hydroxyapatite prepared by chemically converting hydroxyapatite nanocrystals to fluoroapatite with a fluorine reagent.
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07/02/2009 |
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| Bulletin: Chimeric IgG Monoclonal Antibody Purification |
This tech note describes the purification of a chimeric IgG
mAb using a two-step purification platform consisting of
UNOsphere SUPrA™ medium capture followed by a CHT
ceramic hydroxyapatite or CFT ceramic fluoroapatite media
polishing step. The results demonstrate that both CHT and
CFT deliver highly purified chimeric IgG by removing leached
protein A, host cell protein (HCP), DNA, and mAb aggregates. |
07/02/2009 |
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| White Paper: Automated, Single-Use Purification Platforms In Biopharmaceutical Production |
The use of disposable bioreactors and single-use purification platforms for Normal Flow Filtration (NFF), Tangetial Flow Filtration(TFF) and Preparative Chromatography have received significant attention in years. Up to very recently, the use of single-use purification platforms was limited almost exclusively to manually operated systems. The transitioning from manual to automated single-use purification systems has been limited primarily by the availability of appropriate sensors and detectors and other in-line system components. By Karl G. Schick, Ph.D., VP of R&D, SciLog Inc. |
07/02/2009 |
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| Application Note: Evaluation Of PARP Inhibitors: Performed On BMG LABTECH’s FLUOstar Omega |
Poly ADP-ribosylation is a post-translational modification
of proteins that plays a crucial role in regulating DNA repair.
Poly (ADP-ribose) polymerase (PARP) transfers ADP-ribose
to itself and other nuclear proteins such as histones. The
substrate for that reaction is NAD+. By BMG LABTECH, GmbH
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07/01/2009 |
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| Article: Unraveling Threads - VP's Guide To Our Threaded Connectors |
Have you ever found yourself searching for a threaded connector only to end up with more questions than when you started? The Value Plastics team answers hundreds of technical calls every month from customers worldwide – from medical device OEM and similar high tech fields. By Value Plastics |
06/25/2009 |
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| Bulletin: Bio-Rad Process Chromatography Applications Laboratory |
Bio-Rad Laboratories welcomes you to our pilot-scale development laboratory for process chromatography located at our headquarters in Hercules, California. |
06/25/2009 |
6.79 MB |
| Bulletin: Bio-Rad Process Chromatography Applications Laboratory |
Bio-Rad Laboratories welcomes you to our pilot-scale development laboratory for process chromatography located at our headquarters in Hercules, California. The laboratory offers access to state-of-the-art chromatography equipment and media and to the expertise of our team of separations scientists and engineers. |
06/24/2009 |
6.79 MB |
| Bulletin: Bio-Rad Process Chromatography Applications Laboratory |
Bio-Rad Laboratories welcomes you to our pilot-scale development laboratory for process chromatography located at our headquarters in Hercules, California. The laboratory offers access to state-of-the-art chromatography equipment and media and to the expertise of our team of separations scientists and engineers. |
06/24/2009 |
6.79 MB |
| Bulletin: Bio-Rad Process Chromatography Applications Laboratory |
Bio-Rad Laboratories welcomes you to our pilot-scale development laboratory for process chromatography located at our headquarters in Hercules, California. The laboratory offers access to state-of-the-art chromatography equipment and media and to the expertise of our team of separations scientists and engineers. |
06/24/2009 |
6.79 MB |
| White Paper: Research Efficiency In Hard Times: It’s Time To Adapt |
Nobody likes hard times, but they do have one redeeming quality: They focus attention on areas neglected in good times. The need for greater efficiency is a prime example, especially for small drug development companies. Even in the best of times, they must cope with the formidable combination of high costs, long timelines, and low success rates. And when hard times come, they feel it first and most acutely. These companies should be the first to ask: Is there a better way? By Michael Rosenberg, M.D., MPH, Life Science Leader magazine |
06/23/2009 |
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| Brochure: XPert® TXE™ Equipment Enclosures |
XPert® TXE™ Equipment Enclosure is designed to address the needs of
pharmaceutical research and quality control laboratories. It provides a
safe, ventilated space for keeping powder-generating apparatus
contained. Its tall 42" interior height accommodates equipment such
as pill presses, grinders, crushers and sieves. HEPA-filtered air is
returned to the laboratory. |
06/19/2009 |
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| White Paper: Advances In Ventilated Balance Enclosure Technology Bring Safety Enhancements To The Pharmaceutical Industry |
This paper investigates the challenges inherent in using traditional laboratory
containment equipment to safeguard workers handling powdered
toxic substances, and the opportunities provided by innovative solutions
designed to better protect workers. By Labconco
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06/19/2009 |
242.3 KB |
| White Paper: The Key Considerations Of Clinical Trials |
Clinical trials are only a small part of the research that goes into developing a new treatment. Drugs of the future, for example, first have to be discovered, purified, described, and tested in labs (in cell and animal studies) before ever reaching human clinical trials. About 1,000 potential drugs are tested before just one reaches the point of being tested in a clinical trial. By William McGinnis, Life Science Leader magazine |
06/18/2009 |
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| White Paper: Good Housekeeping: The Art Of Contamination Controls |
It took Dr. Joseph Lister a while to convince physicians that something invisible had to be protected against, but since the concept took hold, cleanliness has been a major concern in life sciences. Now there are numerous standards defining “clean” in hospitals, pharmaceutical manufacturers, biotech labs, and other life sciences areas, plus numerous options for meeting those standards. By Wendy Meyerhoff, Life Science Leader magazine |
06/18/2009 |
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| Article: Scaling Up From Bench Through Commercialization |
A biopharmaceutical scientist’s scale-up journey often starts when he or she gets some sketchy information from a research colleague on “an exciting molecule with great biological activities!” The challenge begins with establishing a cell line, then involves scaling up the process to a pilot scale and producing initial material by means of a suboptimal process. Process knowledge increases exponentially from the first experiment until when a company has finally scaled its process up to a commercial scale. By Maninder Hora |
06/17/2009 |
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| Article: Process Development: Turning Science Into Technology |
Manufacturing process development is crucial to the success of a biotherapeutic entity. Even the best “miracle drug” will make it to just a select few patients if it’s too expensive to make—and if it’s too delicate to survive processing and/or delivery, even that may be too much to ask. By Cheryl Scott |
06/17/2009 |
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| Article: Analytical Instrument Qualification |
Current GxP regulations require
analytical instruments to be
qualified to demonstrate
suitability for their intended
use. By Wolfgang Winter |
06/17/2009 |
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| Article: Ultrasensitive Calorimetry: One Of The Best Kept (And Advanced) R&D Secrets? |
Remember when you performed your first calorimetric test? Perhaps it was the classic Styrofoam cup test or the more sophisticated “bomb” (combustion chamber) calorimeter that allowed you to measure heat changes on large samples with remarkable accuracy. By Rusty Russell |
06/17/2009 |
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| Article: The Case For 'Good Storage Practice' In Biopharmaceutical Development |
Those working in medical
research and drug development
have always needed to store
biological materials such as
blood samples and active
pharmaceutical ingredients. Stored
biomaterials can be used for a number
of purposes, from medical education
to examination of disease processes
over time. By F. John Mills, Oscar Moralez, and Jennifer Benner |
06/17/2009 |
1.65 MB |
| Article: A Bioassay Glossary |
In the biopharmaceutical industry, white papers,
standards, and regulatory documents are often
published in draft form to elicit comments from
industry over a designed review period. By Robert Singer, David M. Lansky, and Walter W. Hauck |
06/17/2009 |
2.67 MB |
| Hamilton Free Pipette Offer |
Select the free Hamilton pipette of your choice and order tips at factory direct prices. |
06/16/2009 |
420.3 KB |
| Hamilton Pipette Trade-In Offer |
Trade in any brand pipette for a Hamilton SoftGrip manual single channel or multi-channel pipette or a SofTouch electronic single channel or multi-channel pipette at a discounted price. Please use the form on the back to return your pipettes to Hamilton. |
06/16/2009 |
195.7 KB |
