Articles
The Reoccurrence Of Mycoplasma Contamination: Prevention Strategies
March 26, 2010
•Article: The Reoccurrence Of Mycoplasma Contamination: Prevention Strategies
By James A. Akers, Theodore H. Meltzer, and Maik W. Jornitz
The contamination of microbiological media by mycoplasmas such as Acholeplasma laidlawii is not a recent phenomenon. It has been a major problem with animal-derived sera since the 1980s and has been a concern in the management of cell cultures for decades. The main culprit of serum contamination was the inadequate blood collection methodology and was eliminated with the introduction of hollow collection needles. In addition to the introduction of an improved collection method, serum was filtered with 0.1 µm-rated membrane filters to isolate potential mollicute contaminants, albeit with varying degrees of success.
Reprinted with permission from BioProcess International
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