Articles
Rapid Functional Screening At Dopamine Receptors By Measuring Intracellular Calcium With The NOVOstar Fluorescence Reader
October 5, 2006
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•Application Note: Rapid Functional Screening At Dopamine Receptors By Measuring Intracellular Calcium With The NOVOstar Fluorescence Reader
•Application Note: Rapid Functional Screening At Dopamine Receptors By Measuring Intracellular Calcium With The NOVOstar Fluorescence Reader
SOURCE: BMG LABTECH, GmbH
•Application Note: Rapid Functional Screening At Dopamine Receptors By Measuring Intracellular Calcium With The NOVOstar Fluorescence Reader
Calcium is a common second messenger released upon stimulation of different G-protein coupled receptors (GPCRs). Measuring intracellular calcium is therefore a widely applicable method for functional screening of compounds at various GPCRs. Here, a fast and sensitive method to screen compounds sequentially for agonism or antagonism at human dopamine hD1 and hD2L receptors (Gs/Gi/q coupled) recombinantly expressed in HEK293 cells was developed by using the NOVOstar fluorescence microplate reader from BMG LABTECH, Offenburg, Germany.
Click Here To Download:
•Application Note: Rapid Functional Screening At Dopamine Receptors By Measuring Intracellular Calcium With The NOVOstar Fluorescence Reader
SOURCE: BMG LABTECH, GmbH
