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Preparation Of Redundant, Disposable Filtration Systems

April 8, 2009

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Feature Article: Preparation Of Redundant, Disposable Filtration Systems

By Kerry Roche Lentine, Laurence Gries, Mark Mcinnes, Joseph Chartier

Disposable filtration systems eliminate the need for end users to conduct (and validate) clean-in-place or sterilization steps. Such systems are increasing in use and in design complexity for pharmaceutical processes. Redundant disposable filtration sytems are of i nterest because end users are including two sterilizing-grade filter housings or capsules in series to meet regulatory expectations or process objectives. Disposable systems are prepared similarly to cartridges-in-steel systems and must be able to handle the same pressures and operating steps that will be used before product filtration.

Reprinted with permission from BioProcess International 4(4) (June 2006)

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Feature Article: Preparation Of Redundant, Disposable Filtration Systems

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