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•Application Note: PHERAstar: A Next Generation Multimode Plate Reader For Sophisticated HTS Assays

The High-Throughput Screening (HTS) approach to drug discovery has gained widespread popularity over the last 15 years. Because of the need to process thousands of assays per day, HTS relied upon multiple-well microplates and robotic processing technologies. Pressure for increase in throughput and reduction in cost led to the adoption of high-density, lower-volume microplates as well as fast, homogeneous, miniaturizable screening assays.

BMG LABTECH's PHERAstar combines rapid plate reading necessary for HTS with enhanced performance and sensitivity needed to read small liquid volumes.

This new multimode microplate reader has the flexibility to excel with the most demanding assays and is designed to read all leading HTS detection modes (fluorescence intensity, time-resolved fluorescence, fluorescence polarization, luminescence and absorbance) in all formats up to 1536.

The PHERAstar has been applied to a number of assays, including protein- protein binding, ligand-receptor binding, enzyme activity assays, molecular biological applications and second messenger quantification. The performance and features of the PHERAstar are presented in this application note with commercially available HTS kits such as Far Red PolarScreen™, AlphaScreen™, and HTRF®.

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•Application Note: PHERAstar: A Next Generation Multimode Plate Reader For Sophisticated HTS Assays

SOURCE: BMG LABTECH, GmbH