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11.26.2008 -- New Research Helps Explain Genetics Of Parkinson's Disease

November 26, 2008

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Anti SQSTM1/A170/p62, Rabbit

Sequestosome 1 (SQSTM1)/A170 (mouse)/p62 (human)/ZIP (rat) is an ubiquitin-binding protein that expresses oxidative stress-dependently. Abnormality of SQSTM1 leads to bone metabolic disorder, obesity, and Type II Diabetes. Wako has launched the mouse SQSTM1 (A170) rabbit antiserum, which is applicable to Western blot, IHC, and immunofluorescence.

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Featured Articles
Addressing Product Improvement Using Chemical Modification In Biopharmaceutical Manufacture
By Roger L. Lundblad and Ralph A. Bradshaw, BioProcess International
Any modification of a natural protein (by either chemical means or site-directed mutagenesis) for use as a biotherapeutic immediately raises the issue of immunogenicity and, to a lesser extent, stability. Indeed, development of antibodies against therapeutics is receiving increased study. Immune reactions secondary to administration of protein therapeutics is not a new problem and was a major issue with animal-derived insulin products.
Read the complete article.

Chlorine Dioxide, Part 2
By Barry Wintner, Anthony Contino, and Gary O'Neill, BioProcess International
CD has been demonstrated effective in both the aqueous and gas phases, which is highly advantageous for biopharmaceutical applications. It is easy to change CD from one state to the other. One benefit of the membrane sachet technology (see below) is that it can be used to generate an aqueous solution that can be stored until needed.
Read the complete article.

Top News Stories
New Research Helps Explain Genetics Of Parkinson's Disease
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MIT Engineers Show How Tiny Cell Proteins Generate Force To 'Walk'
New Diabetes Treatment?
Microarray Analysis Improves Prenatal Diagnosis
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Particle Sizing Seminars Stimulate Lively Discussion
Scientists Shed Light On How DNA Is Unwound So That Its Code Can Be Read
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Virtis Ultra Lyophilizer
The Virtis Ultra Series Freeze Dryer has been re-engineered to handle all of your applications from phase 1 research through production clinical trial batches. Download the product brochure for more information.

Standard Bioprocessing Flexboy® Bags
Standard Flexboy Bioprocessing Bags are designed for the preparation, storage, and transport of biopharmaceutical solutions, intermediates, and final bulk products. Standard Flexboys are available as sterilized and ready-to-use stand-alone bags, or filter and bag assemblies incorporating a variety of tubing, connections, filters, and bag sizes (from 50ml to 50L). Download the product brochure for more information.

L-Tyrosine Amino Acid (L-Tyr)
Ajinomoto is the premier amino acid manufacturer and supplier of bulk pharmaceutical grade amino acids with fifty years of production expertise. The same L-Tyrosine amino acid produced in bulk is also available in a small package size for research and development applications. Download the product datasheet for more information.

Thermo Scientific Finntip Pipette Tips
Finntips are manufactured using high quality raw materials and the latest molding techniques, and they are designed using our knowledge of liquid handling. Download the product brochure for more information.

Contract Testing Services
The Limulus Amebocyte Lysate (LAL) testing is a method for the detection and quantitation of bacterial lipopolysaccharides (endotoxins). Download the product brochure for more information.

NEWMIX™ Jet-Drive&trade
The Newmix™ Jet-Drive™ system is one of the lightest and most compact disposable mixing systems available on the market. It fits equally well into both development and manufacturing cGMP environments where portability, high mixing efficiency, ease of use, and a small footprint are invaluable assets. Download the product datasheet for more information.

Vetter Commercial Manufacturing
Concentrate and focus your resources. Leave the details of production to us, your specialist and loyal partner. Vetter Commercial Manufacturing can handle everything for you — from the initial stages of sterilization through the custom-packaging of your final product. Download the product datasheet for more information.

Centrifuges: CEPA High-Speed Centrifuges for Separation And Solids Removal From Liquids
The CEPA family of high-speed centrifuges is widely used in a variety of biological processes from cell harvesting and clarifying to separations of chemicals, foods, blood and pharmaceuticals. Request more information.

FiberFlo® FPNN All-Nylon Pleated Cartridge Filters
FiberFlo "NN" all-nylon cartridges are absolute rated. Made with nylon membrane, cage, core, end caps, and support media, the cartridges have high surface area with excellent flow rates per 10-inch length. Download the product datasheet for more information.

NALGENE Specialized Flexible Packaging Solutions
Flexible Packaging offers a wide range of capabilities to meet your varied dispensing and storage needs. Download the product datasheet for more information.

Featured Download
Brochure: LONG®R3IGF-I — Your Insulin Alternative
LONG®R3IGF-I is a dedicated raw material manufactured exclusively for cell culture applications. It provides a consistent, compliant, and reliable alternative to recombinant insulin. It is not subject to market fluctuations and shortages as is recombinant insulin.
Application Note: Inductively Coupled Plasma Spectroscopy (ICP)
Inductively coupled plasma spectroscopy (ICP) is used to detect trace metals from environmental samples. Three concentric tubes make up what is known as the torch.
2009 Pittcon Conferee Brochure
It's the scientific event of the year, and from March 8 to March 13, 2009, more than 20,000 attendees will gather at Pittcon in Chicago, Illinois to see what's new, exchange ideas, and learn. Pittcon is a unique experience where you can advance your own scientific interests and gather technical information that will help you back in the lab. Take a moment and see all of the possibilities.
Brochure: Oligonucleotide And Peptide Synthesizers
TechniKrom® provides pilot and production scale (10 µmol–1 mol) automated synthesis units for use in the biopharmaceutical, pharmaceutical and fine chemical industries.
Datasheet: Sampling Unit
The Sampling Unit enables the automatic withdrawal and storage of liquid samples at laboratory-scale from bioreactors.
Life Science Leader

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Featured Events
The Center For Professional Innovation And Education

Selecting And Managing CROs
December 2 and 3
Malvern, PA

Effective Risk-Based Applications Of Drug cGMPs And Validation Requirements For Cosmetics And OTC Drug Products
December 8 and 9
Malvern, PA

Pharmaceutical Maintenance Management: Understanding cGMPs
December 8 and 9
Malvern, PA

BMD Summit
The BMD Summit is the one forum where you can learn the newest uses for disposables or learn how to apply the best principles for operational excellence to achieve lean manufacturing, or both!
December 8 and 9
Washington Duke Inn & Golf Club
Durham, NC
The Williamsburg BioProcessing Foundation Conferences:
Cell Banking/Cell Engineering
December 2-4
Santa Barbara, CA

Characterization And Comparability For Biologics
December 8-10
Baltimore, MD
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Biomanufacturing Summit '09
Increase your speed to market and process efficencies!
January 27 and 28, 2009
San Diego, CA
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