Articles
Milling Technologies Used In Cell Culture Media Manufacture
June 8, 2007
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•Milling Technologies Used In Cell Culture Media Manufacture
Milling is the act of processing raw materials using
machinery that grinds, compresses, or pulverizes
the materials. It is a particle size reduction process.
This process is achieved using a variety of machinery that
applies one or more forces to refine particle sizes.
Ball Mills
Ball mills are the oldest and most common type of cell culture
media mill. Ball mills can reduce material continuously or in
batches and can be run wet or dry. The mill itself is composed
of a horizontal cylinder with grinding media, in the form of
spheres, added to aid in particle size reduction. Ceramic
grinding media are used for processes that require iron–
contamination-free processing, such as biopharmaceutical
applications. Ball mills reduce particles through the impact of
media against the mill wall as the cylinder rotates. As the media
tumbles, it crushes the feed material that is caught between the
mill wall and the media. Ball mills can produce particle sizes
below 100 µm. With time, wear on the ceramic media spheres
will occur, necessitating replacement.
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•Milling Technologies Used In Cell Culture Media Manufacture
SOURCE: SAFC
