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Fourier-Transform Midinfrared Spectroscopy For Analysis And Screening Of Liquid Protein Formulations, Part 2
March 6, 2009
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•Article: Fourier-Transform Midinfrared Spectroscopy For Analysis And Screening Of Liquid Protein Formulations, Part 2
•Article: Fourier-Transform Midinfrared Spectroscopy For Analysis And Screening Of Liquid Protein Formulations, Part 2
•Article: Fourier-Transform Midinfrared Spectroscopy For Analysis And Screening Of Liquid Protein Formulations, Part 2
By Patrick Garidel and Heidrun Schott
In the first half of this two-part article (1), we introduced the physical principle behind infrared (IR) absorptions and experimental setups used for investigating protein samples. This second part concludes by focusing on the use of IR spectroscopic data in formulation stability studies and for characterizing protein secondary structures and related changes (e.g., resulting from protein–excipient interactions). We also examine IR's use in screening protein formulations.
Reprinted with permission from BioProcess International 4(6):48-55 (June 2006)
Click Here To Download:•Article: Fourier-Transform Midinfrared Spectroscopy For Analysis And Screening Of Liquid Protein Formulations, Part 2
