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Evaluation And Implementation Of A Single-Stage Multimedia Harvest Depth Filter For A Large-Scale Antibody Process

September 17, 2009

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Article: Evaluation And Implementation Of A Single-Stage Multimedia Harvest Depth Filter For A Large-Scale Antibody Process

By Purav Dave, Jemelle Dizon-Maspat, and Tony Cano

Typical large-scale antibody recovery processes begin with harvesting Chinese hamster ovary (CHO) cell culture fluid (CCF) at the end of a culture cycle. The harvest involves separating secreted product (antibodies) from whole cells and cell debris present in the CCF. Traditionally, this is done using a tangential-flow filtration (TFF) system or centrifuge in conjunction with depth filtration.

Reprinted with permission from BioProcess International 7(6) (June 2009)

Click Here To Download:
Article: Evaluation And Implementation Of A Single-Stage Multimedia Harvest Depth Filter For A Large-Scale Antibody Process

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