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Carbonxymethyl Starch, pH-Sensitive Polymeric Matrix For Controlled Drug Release: Influence Of The Degree Of Substitution
July 23, 2009
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•Poster: Carbonxymethyl Starch, pH-Sensitive Polymeric Matrix For Controlled Drug Release: Influence Of The Degree Of Substitution
•Poster: Carbonxymethyl Starch, pH-Sensitive Polymeric Matrix For Controlled Drug Release: Influence Of The Degree Of Substitution
•Poster: Carbonxymethyl Starch, pH-Sensitive Polymeric Matrix For Controlled Drug Release: Influence Of The Degree Of Substitution
By Marc Lemieux, Patrick Gosselin, and Mircea Alexandru Mateescu
Carboxymethyl high amylose starch (CM-HAS) is an excipient able to control the release of small and large active molecules [1-4] as well as bioactive agents [5-7] up to 15h from monolithic tablets loaded with 20 to 60% of drug. The CM-HAS used in these studies were produced by homogenous synthesis process (aqueous) for which a maximum degree of substitution (DS) of 0.3 can be obtained with a reaction yield under 40%. Although the liberation characteristics for low DS are known, they are not yet known for higher DS.
Click Here To Download:•Poster: Carbonxymethyl Starch, pH-Sensitive Polymeric Matrix For Controlled Drug Release: Influence Of The Degree Of Substitution
