Articles
RSSCalibration Free Supersaturation Assessment and Control For The Development And Optimization of Crystallization Processes
February 4, 2010
Due to popular demand, METTLER TOLEDO is re-running the Calibration Free Supersaturation Assessment and Control for the Development and Optimization of Crystallization Processes webinar.
Development and scale-up experiments are performed in a 100ml and 1L scale automated laboratory reactors. These laboratory reactor platforms, used in conjunction with PAT technologies, are used to develop and optimize the crystallization of both an Active Pharmaceutical Ingredient (API) and benzoic acid. The use of this methodology for assessing and solving laboratory based tech transfers and scale-up issues is also demonstrated.
The use of a commercially available software package is shown to implement an open loop feedback control strategy, used in conjunction with ATR-FTIR peak height values. The presented strategy demonstrates how qualitative supersaturation trajectories can be controlled to a specific set point and in turn ensure particle dimension and quality are not jeopardized in the tech transfer and scale-up of these processes.
The knowledge gained when coupled with in situ particle dimension information significantly increase process understanding and as a result minimal experimentation is required to output a desirable crystallization process.
METTLER TOLEDO is a leading global manufacturer of precision instruments. The Company is the world's largest manufacturer and marketer of weighing instruments for use in laboratory, industrial and food retailing applications. The Company also holds top-three market positions in several related analytical instruments and is a leading provider of automated chemistry systems used in drug and chemical compound discovery and development. In addition, the Company is the world's largest manufacturer and marketer of metal detection systems used in production and packaging.
SOURCE: METTLER TOLEDO
