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•Application Note: Nephelometric Monitoring Growth Of Candida Albicans Using BMG LABTECH's NEPHELOstar

Cyclodextrins (CD) have become useful pharmaceutical excipients, due to their potential to form inclusion complexes with appropriately sized drug molecules. The resulting complexes generally offer a variety of physicochemical advantages over the free drug, including increased water solubility, enhanced bioavailability, improved stability, reduced side effects, etc.

Econazole-nitrate (EC) and ciclopirox-olamine (CI) are well known antifungal agents suitable for the treatment of many mycotic infections. Previous studies showed that both dissolution properties and consequently microbiological activities of econazole, with very low water solubility (about 3 µg/mL at 25°C), can be improved by complexation with natural cyclodextrins, particularly with ß-CD3-5. By increasing the water solubility of the drug it should be possible to improve its bioavailability, thus enabling improved oral or topical formulations.

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•Application Note: Nephelometric Monitoring Growth Of Candida Albicans Using BMG LABTECH's NEPHELOstar