News Articles http://www.bioresearchonline.com/ 12/25/2008 12:56:00 AM The Alzheimer's Drug Discovery Foundation (ADDF) announced recently that it provided a grant of $185,000 to Varinel, Inc., an emerging pharmaceutical company dedicated to developing drugs that can prevent neuronal degeneration and improve brain function. The grant will assist Varinel in advancing the preclinical development of its multifunctional lead compounds, VAR10300 (also known as M30). http://www.bioresearchonline.com/article.mvc/Alzheimers-Drug-Discovery-Foundation-Funds-0001?atc~c=771+s=773+r=001+l=a 12/25/2008 12:56:00 AM President-Elect Barack Obama has announced that soon after his inauguration, he will lift the ban on federally funding research using additional lines of human embryonic stem cells. This action is the first of many steps necessary for the development of new stem cell therapies. http://www.bioresearchonline.com/article.mvc/Rescinding-The-Ban-On-Embryonic-Stem-Cell-0001?atc~c=771+s=773+r=001+l=a 12/24/2008 2:06:00 AM NanoVector, Inc. announced today that it has licensed the plant virus nanoparticle drug delivery system developed by Professors' Stefan Franzen and Steven Lommel from North Carolina State University. http://www.bioresearchonline.com/article.mvc/NanoVector-to-Commercialize-First-Biologic-Na-0001?atc~c=771+s=773+r=001+l=a 12/2/2008 8:00:00 AM In its special 50th anniversary issue (September 2008), Applied Spectroscopy paid tribute to a groundbreaking paper which heralded the birth of a solid-state approach to chemical imaging. http://www.bioresearchonline.com/article.mvc/Malvern-director-groundbreaking-research-0003?atc~c=771+s=773+r=001+l=a 12/2/2008 4:01:00 AM Symyx Technologies, Inc. recently announced the availability of Symyx Registration 1.5. This major new release offers R&D organizations of all sizes a flexible, fully featured, Isentris-based approach to building and managing consistent, searchable, and shareable corporate compound registries based on Symyx's industry-leading chemical representation technology. Out-of-the-box integration with Symyx Assay Explorer® biology data management software enables researchers to view chemically registered substances alongside biological assay results, facilitating SAR analysis and the prioritization of new compounds for testing. http://www.bioresearchonline.com/article.mvc/Symyx-Registration-15-Software-Provides-Out-0001?atc~c=771+s=773+r=001+l=a 12/2/2008 3:54:00 AM The genome of a squirrel-sized, saucer-eyed lemur from Madagascar may help scientists understand how HIV-like viruses coevolved with primates, according to new research from the Stanford University School of Medicine. The discovery, to be published online on Dec. 1 in the Proceedings of the National Academy of Sciences, could provide insight into why non-human primates don't get AIDS and lead to treatments for humans. http://www.bioresearchonline.com/article.mvc/Discovery-Of-Virus-In-Lemur-Could-Shed-Light-0001?atc~c=771+s=773+r=001+l=a 12/2/2008 3:31:00 AM College students who are vaccinated against influenza appear less likely to develop flu-like illnesses, require related health care visits or experience impairments in academic performance during flu season, according to a new report. http://www.bioresearchonline.com/article.mvc/Flu-Vaccine-Linked-To-Reduced-Illness-0001?atc~c=771+s=773+r=001+l=a 12/2/2008 3:28:00 AM The bacterium Pseudomonas aeruginosa is well known for its environmental versatility, ability to cause infection in humans, and its capacity to resist antibiotics. P. aeruginosa is the most common cause of persistent and fatal lung infections in cystic fibrosis patients. In a study published online in Genome Research, researchers have used genomic techniques to study a particularly virulent strain of P. aeruginosa, uncovering genetic clues to its success that will aid in the design of novel therapeutic strategies. http://www.bioresearchonline.com/article.mvc/Viral-DNA-In-Bacterial-Genome-Could-Hold-Key-0001?atc~c=771+s=773+r=001+l=a 12/2/2008 3:24:00 AM Like tuning a violin to produce strong, elegant notes, researchers at The Wistar Institute have found multiple receptors on the outside of the body's killer immune system cells which they believe can be selectively targeted to keep the cells in superb infection- and disease-fighting condition. http://www.bioresearchonline.com/article.mvc/Key-To-Keeping-Killer-T-Cells-In-Prime-Shape-0001?atc~c=771+s=773+r=001+l=a 12/2/2008 3:20:00 AM Current research suggests that melatonin therapy may help treat uveitis, a common inflammatory eye disease. http://www.bioresearchonline.com/article.mvc/Study-Finds-Therapy-That-May-Save-Eyesight-0001?atc~c=771+s=773+r=001+l=a 12/1/2008 8:27:00 AM Common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population, according to a new article. An international team of researchers, led by Karsten Suhre, has conducted a genome-wide association study with metabolomics, identifying genetic variants in genes involved in the breakdown of fats. http://www.bioresearchonline.com/article.mvc/Genetic-Variants-Giving-Rise-To-Differences-0001?atc~c=771+s=773+r=001+l=a 12/1/2008 8:16:00 AM Faint magnetic signals from brain activity in children with autism show that those children process sound and language differently from non-autistic children. http://www.bioresearchonline.com/article.mvc/Brains-Magnetic-Fields-Reveal-Language-Delay-0001?atc~c=771+s=773+r=001+l=a 12/1/2008 8:12:00 AM Antibiotics are the single largest class of agents that cause idiosyncratic drug-induced liver injury (DILI), reports a new study in Gastroenterology, an official journal of the American Gastroenterological Association (AGA) Institute. http://www.bioresearchonline.com/article.mvc/Single-largest-class-of-drugs-causing-liver-0001?atc~c=771+s=773+r=001+l=a 12/1/2008 8:09:00 AM The December 2008 issue of BioScience includes a Special Section consisting of four articles on Endocrine Disruptors in the Environment, coordinated by Louis J. Guillette, Jr., of the University of Florida. http://www.bioresearchonline.com/article.mvc/BioScience-tip-sheet-December-2008-0001?atc~c=771+s=773+r=001+l=a 12/1/2008 8:02:00 AM Flip open any biology textbook and you're bound to see a complicated diagram of the inner workings of a cell, with its internal scaffolding, the cytoskeleton, and how it maintains a cell's shape. Yet the fundamental question remains, which came first: the shape, or the skeleton? http://www.bioresearchonline.com/article.mvc/Cells-Reorganize-Shape-To-Fit-The-Situation-0001?atc~c=771+s=773+r=001+l=a 12/1/2008 3:37:00 AM Pharmaceutical company Novogen Limited, recently announced that work performed in collaboration with a Yale University research team led by Associate Professor Gil Mor, MD, PhD, has revealed its novel mTOR inhibitor NV-128 has the potential to act against cancer stem cells in addition to rapidly proliferating cells in established solid tumors. http://www.bioresearchonline.com/article.mvc/Novogens-NV-128-A-Novel-mTOR-Inhibitor-Shows-0001?atc~c=771+s=773+r=001+l=a 12/1/2008 3:22:00 AM DOR BioPharma, Inc. ("DOR" or the "Company") announced recently that it has received $1.5 M under a letter of intent with Sigma-Tau Pharmaceuticals, Inc. ("Sigma-Tau"), which grants Sigma-Tau an exclusive right to negotiate terms and conditions for a possible business transaction or strategic alliance regarding orBec® (oral beclomethasone dipropionate or oral BDP) and potentially other DOR pipeline compounds until March 1, 2009. http://www.bioresearchonline.com/article.mvc/DOR-BioPharma-Receives-15-M-From-Sigma-Tau-0001?atc~c=771+s=773+r=001+l=a 12/1/2008 2:46:00 AM A study describing how cells within blood vessel walls move en masse overturns an assumption common in the age of genomics-that the proteins driving cell behavior are doing so much multitasking that it would be near impossible to group them according to a few discrete functions. But now researchers at the Stanford University School of Medicine have shown that distinct groups of proteins each control one of four simple activities involved in the cells' http://www.bioresearchonline.com/article.mvc/Cell-Movements-Totally-Modular-Stanford-Study-0001?atc~c=771+s=773+r=001+l=a 11/30/2008 5:00:00 PM Writing in this week's Journal of the American Medical Association, UC Davis M.I.N.D. Institute researchers urge physicians to test for mutations of the fragile X gene in patients of all ages. That's because, after decades of research, it is clear that mutations in this gene cause a range of diseases, including neurodevelopmental delays and autism in children, infertility in women and neurodegenerative disease in older adults. http://www.bioresearchonline.com/article.mvc/MIND-Institute-Researchers-Call-For-Fragile-X-0001?atc~c=771+s=773+r=001+l=a 11/27/2008 2:47:00 AM Friction is the bane of any machine. When moving parts are subject to friction, it takes more energy to move them, the machine doesn't operate as efficiently, and the parts have a tendency to wear out over time. http://www.bioresearchonline.com/article.mvc/Nanocoatings-Boost-Industrial-Energy-0002?atc~c=771+s=773+r=001+l=a 11/26/2008 5:32:00 AM